Publications

Haiyi Mao, Romain Lopez, Kai Liu, Panayiotis v. Benos, Lin Qiu (2024). Learning Identifiable Factorized Causal Representations of Cellular Responses. Advances in Neural Information Processing Systems.
PDF Cite
Pouya M Ghari, Alex Tseng, Gökcen Eraslan, Romain Lopez, Tommaso Biancalani, Gabriele Scalia, Ehsan Hajiramezanali (2024). Generative Flow Networks Assisted Biological Sequence Editing. Advances in Neural Information Processing Systems.
PDF Cite
Jayoung Ryu, Charlotte Bunne, Lucas Pinello, Aviv Regev*, Romain Lopez* (2024). Cross-modality Matching and Prediction of Perturbation Responses with Labeled Gromov-Wasserstein Optimal Transport. Machine Learning in Computational Biology (MLCB).
PDF Cite
Mahtab Bigverdi, Burkhard Hockendorf, Heming Yao, Phil Hanslovsky, Romain Lopez, David Richmond (2024). Gene-Level Representation Learning via Interventional Style Transfer in Optical Pooled Screening. CVPR Workshop on Computer Vision for Microscopy Images.
PDF Cite
Romain Lopez, Jan-Christian Huetter, Ehsan Hajiramezanali, Jonathan Pritchard, Aviv Regev (2024). Toward the Identifiability of Comparative Deep Generative Models. Causal Learning and Reasoning.
PDF Cite
Malte D Luecken, Scott Gigante, Daniel B Burkhardt, Robrecht Cannoodt, Daniel C Strobl, Nikolay S Markov, Luke Zappia, The Open Problems Jamboree Members, et al. (2024). Defining and benchmarking open problems in single-cell analysis. Research Square.
PDF Cite
Kexin Huang, Romain Lopez, Jan-Christian Hütter, Takamasa Kudo, Antonio Rios, Aviv Regev (2024). Sequential optimal experimental design of perturbation screens guided by multi-modal priors. Research in Computational Molecular Biology (RECOMB).
PDF Cite
Zitong Jerry Wang, Romain Lopez, Jan-Christian Hütter, Takamasa Kudo, Heming Yao, Philipp Hanslovsky, Burkhard Höckendorf, Aviv Regev (2024). Multi-ContrastiveVAE disentangles perturbation effects in single cell images from optical pooled screens. ICLR Workshop on Machine Learning for Genomics Explorations.
PDF Cite
Xinming Tu, Jan-Christian Hutter, Zitong Jerry Wang, Takamasa Kudo, Aviv Regev, Romain Lopez (2023). A Supervised Contrastive Framework for Learning Disentangled Representations of Cell Perturbation Data. Machine Learning in Computational Biology (MLCB).
PDF Cite
Pouya M Ghari, Alex Tseng, Gökcen Eraslan, Romain Lopez, Tommaso Biancalani, Gabriele Scalia, Ehsan Hajiramezanali (2023). Generative Flow Networks Assisted Biological Sequence Editing. NeurIPS Workshop on Generative AI and Biology.
PDF Cite
Isaac Virshup, Danila Bredikhin, Lukas Heumos, Giovanni Palla, Gregor Sturm, Adam Gayoso, Ilia Kats, Mikaela Koutrouli, Scverse Community, et al. (2023). The scverse project provides a computational ecosystem for single-cell omics data analysis. Nature Biotechnology.
PDF Cite
Muralikrishnna G. Sethuraman, Romain Lopez, Rahul Mohan, Faramarz Fekri, Tommaso Biancalani, Jan-Christian Hütter (2023). NODAGS-Flow: Nonlinear cyclic causal structure learning. International Conference on Artificial Intelligence and Statistics.
PDF Cite
Romain Lopez*, Natasa Tagasovska*, Stephen Ra, Kyunghyun Cho, Jonathan K. Pritchard, Aviv Regev (2023). Learning causal representations of single cells via sparse mechanism shift modeling. Conference on Causal Learning and Reasoning.
PDF Code Cite
Pierre Boyeau, Jeffrey Regier, Adam Gayoso, Michael I. Jordan, Romain Lopez*, Nir Yosef* (2023). An empirical Bayes method for differential expression analysis of single cells with deep generative models. Proceedings of the National Academy of Sciences.
PDF Cite
Ethan Weinberger, Romain Lopez, Jan-Christian Hütter, Aviv Regev (2022). Disentangling shared and group-specific variations in single-cell transcriptomics data with multiGroupVI. Machine Learning in Computational Biology (MLCB).
PDF Code Cite
Romain Lopez, Jan-Christian Huetter, Jonathan K. Pritchard, Aviv Regev (2022). Large-scale differentiable causal discovery of factor graphs. Advances in Neural Information Processing Systems.
PDF Code Cite
Romain Lopez*, Baoguo Li*, Hadas Keren-Shaul*, Pierre Boyeau, Merav Kedmi, David Pilzer, Adam Jelinski, Ido Yofe, Eyal David, Allon Wagner, Can Ergen, Yoseph Addadi, Ofra Golani, Franca Ronchese, Michael I Jordan, Ido Amit, Nir Yosef (2022). DestVI identifies continuums of cell types in spatial transcriptomics data. Nature Biotechnology.
PDF Cite
Adam Gayoso*, Romain Lopez*, Galen Xing*, Pierre Boyeau, Katherine Wu, Michael Jayasuriya, Edouard Mehlman, Maxime Langevin, Yining Liu, Jules Samaran, Gabriel Misrachi, Achille Nazaret, Oscar Clivio, Chenling Xu, Tal Ashuach, Mariano Gabitto, Mohammad Lotfollahi, Valentine Svensson, Eduardo Da Veiga Beltrame, Vitalii Kleshchevnikov, Carlos Talavera-Lopez, Lior Pachter, Fabian J Theis, Aaron Streets, Michael I. Jordan, Jeffrey Regier, Nir Yosef (2022). A Python library for probabilistic analysis of single-cell omics data. Nature Biotechnology.
PDF Cite
Khalil Ouardini, Romain Lopez, Matthew G. Jones, Sebastian Prillo, Richard Zhang, Michael I. Jordan, Nir Yosef (2021). Reconstructing unobserved cellular states from paired single-cell lineage tracing and transcriptomics data. ICML Workshop in Computational Biology.
PDF Cite
Romain Lopez (2021). Charting Cellular States, One Cell at a Time: Computational, Inferential and Modeling Perspectives. eScholarship.
PDF Cite
Romain Lopez, Inderjit Dhillon, Michael I. Jordan (2021). Learning from eXtreme bandit feedback. AAAI Conference on Artificial Intelligence.
PDF Cite
Adam Gayoso*, Zoë Steier*, Romain Lopez, Jeffrey Regier, Kristopher L. Nazor, Aaron Streets, Nir Yosef (2021). Joint probabilistic modeling of single-cell multi-omic data with totalVI. Nature Methods.
PDF Code Cite
Chenling Xu*, Romain Lopez*, Edouard Mehlman*, Jeffrey Regier, Michael I. Jordan, Nir Yosef (2021). Probabilistic harmonization and annotation of single-cell transcriptomics data with deep generative models. Molecular Systems Biology.
PDF Code Cite
Romain Lopez, Pierre Boyeau, Nir Yosef, Michael I. Jordan, Jeffrey Regier (2020). Decision-making with auto-encoding variational Bayes. Advances in Neural Information Processing Systems.
PDF Code Cite
Romain Lopez, Adam Gayoso, Nir Yosef (2020). Enhancing scientific discoveries in molecular biology with deep generative models. Molecular Systems Biology.
PDF Cite
Romain Lopez, Chenchen Li, Xiang Yan, Junwu Xiong, Michael I. Jordan, Yuan Qi, Le Song (2020). Cost-effective incentive allocation via structured counterfactual inference. AAAI Conference on Artificial Intelligence.
PDF Cite
Oscar Clivio, Romain Lopez, Jeffrey Regier, Adam Gayoso, Michael I. Jordan, Nir Yosef (2019). Detecting zero-inflated genes in single-cell transcriptomics data. Machine Learning in Computational Biology (MLCB).
PDF Code Cite
Pierre Boyeau, Romain Lopez, Jeffrey Regier, Adam Gayoso, Michael I. Jordan, Nir Yosef (2019). Deep generative models for detecting differential expression in single cells. Machine Learning in Computational Biology (MLCB).
PDF Code Cite
Romain Lopez*, Achille Nazaret*, Maxime Langevin*, Jules Samaran*, Jeffrey Regier*, Michael I. Jordan, Nir Yosef (2019). A joint model of unpaired data from scRNA-seq and spatial transcriptomics for imputing missing gene expression measurements. ICML Workshop in Computational Biology.
PDF Code Cite
Adam Gayoso, Romain Lopez, Zoë Steier, Jeffrey Regier, Aaron Streets, Nir Yosef (2019). A joint model of RNA expression and surface protein abundance in single cells. Machine Learning in Computational Biology (MLCB).
PDF Code Cite
Samuel L. Wolock, Romain Lopez, Allon M. Klein (2019). Scrublet: computational identification of cell doublets in single-cell transcriptomic data. Cell Systems.
PDF Code Cite
Romain Lopez, Jeffrey Regier, Michael B. Cole, Michael I. Jordan, Nir Yosef (2018). Deep generative modeling for single-cell transcriptomics. Nature Methods.
PDF Code Cite
Romain Lopez, Jeffrey Regier, Michael I. Jordan, Nir Yosef (2018). Information constraints on auto-encoding variational Bayes. Advances in Neural Information Processing Systems.
PDF Code Cite
Maxime Langevin, Edouard Mehlman, Jeffrey Regier, Romain Lopez, Michael I. Jordan, Nir Yosef (2018). A deep generative model for semi-supervised classification with noisy labels. Bay Area Machine Learning Symposium.
PDF Code Cite
Romain Lopez, Jeffrey Regier, Michael I. Jordan, Nir Yosef (2017). A deep generative model for gene expression profiles from single-cell RNA sequencing with application to differential expression. NeurIPS Machine Learning workshop in Computational Biology.
PDF Code Cite
Romain Lopez, Jeffrey Regier, Michael I. Jordan, Nir Yosef (2017). A deep generative model for gene expression profiles from single-cell RNA sequencing. Bay Area Machine Learning Symposium.
PDF Code Cite